SCHOTT TopLine Options for Enhanced Processing

SCHOTT TopLyo® – Efficient Lyophilization

Due to a need to accelerate time-to-market cycles and increase shelf life stability of biopharmaceuticals, a keen interest in robust and cost-efficient lyophilization has leapt into the limelight. A streamlined lyo cake is crucial for better-automated  inspectability – and indeed  fundamentally vital to the chief priority  ensuring patient safety. For cristalline formulations, any lensing effect of the vial-bottom during freezing must be avoided.

Thanks to their hydrophobic coating and optimized geometry, SCHOTT TopLyo® vials demonstrate higher mechanical stability during – and less disruption of the lyo cake after – the lyophilization process, in addition to reduced residual volumes and higher dosing accuracy after reconstitution.


Properties:

  • Chemically uniform (Si-O-C-H hydrophobic coating)
  • Layer thickness: ~40 nm
  • Non-porous, covalent bond between glass matrix and coating layer
  • Processability equal to non-coated type I glass vials

Benefits:

  • Cost reduction due to decreased overfilling – given lower residual volume
  • Reduced glass breakage through refined geometry
  • Prevention of lyo cake disruption and sidewall fogging for improved automated inspection
  • Lyo cake stability during transportation
  • Reduced protein aggregation compared to siliconized vials

Sizes:

2R, 6R and 10R ISO formats and lyo bottoms. Customization available on request.

News, Exhibitions & Events
24.
October
Exhibition CPhI / Innopack, Frankfurt, Germany, 10-24 to 10-26-2017
20.
June
Exhibition CPhI China, Shanghai, China, 06-20 to 06-22-2017
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