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SCHOTT Type I plus® – Reduced Drug Container Interaction

Protein adsorption and leaching from primary packaging are known to be root causes of reduced shelf life in sensitive formulations. Metal ion leaching from type I glass leads to a pH shift in water for injectable or unbuffered solutions and can decrease stability or activity of biopharmaceuticals.

SCHOTT Type I plus® vials have an inside SiO2 coating with outstanding barrier properties. This reduces the interaction between drug product and container surface to a bare minimum, thereby providing a superior packaging solution for sensitive ingredients.


  • Chemically uniform: pure silica (SiO2 coating)
  • Layer thickness: 100 – 200 nm
  • Non-porous, covalent bond between glass matrix and coating layer
  • Fill + finish processability equivalent to uncoated type I glass containers
  • Verified barrier owing to a predefined quantitative limit value of 0.17 mg/ml Na for all vial sizes


  • Increased shelf life stability for sensitive drug formulations
  • Minimized adsorption of proteins in liquid formulations – also prior to lyophilization
  • Minimized adsorption of radioactive molecules


2R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R and 100R ISO formats. Customization available on request.