Coated vials from SCHOTT are designed to answer the increasing requirements on the safety and stability of drugs (e.g. no loss of activity due to adsorption). Through the SCHOTT PI-Coating® process, ultra-thin coating layers are applied to the inner surface of the container.
SCHOTT Type I plus® is the vial which drastically reduces interactions between your drug and the container surface. As a result, loss of pharmaceutical ingredient activity due to leachables from the glass is significantly decreased. The benefit is packaging that offers security and stability for your product. more
SCHOTT TopLyo® has distinct properties that makes freeze drying more efficient. Due to the combination of the hydrophobic inner layer and the optimized geometry, the optical quality of the lyophilization–cake stays intact which ensures the functionality of the drug. Also, the risk of glass breakage during the freeze drying is minimized. The advantage is easy to see: a more effective process combined with lower risks equals costs reductions. more
SCHOTT TopYieldTM vials with hydrophobic coating enable a practically complete removal of liquid drugs. The inner layer shows a "lotus effect" that reduces the residual volume caused by adsorption on the glass container surface and avoids the common practice of overfilling to ensure the required drug dosis. Especially for high price drugs the additional costs for overfilling is considerable . more
SCHOTT Type I plus® Pharmaceutical Vials and Pharmaceutical Glass Products
SCHOTT Type I plus® pharmaceutical vials offer security and stability - our pharmaceutical glass drastically reduces interactions between drugs and the container surface.
SCHOTT Type I plus® pharmaceutical vials are particularly suitable for products where conventional packaging of pharmaceutical Type I glass has reached its limits, such as:
Low concentrated proteins with denaturation tendencies
Products that are sensitive to alkalinity (Na+ release is decreased by a factor of 350)
Formulations that react with leachables
Preparations that cannot tolerate a shift of pH value
Radioactive diagnostics that adsorb to the glass surface
SCHOTT Type I plus® pharmaceutical glass is characterized by the purity and inertness of a quartz-like surface (100% SiO2 coating), a thickness of 100 – 200 nm and pharmaceutical properties according to EP, USP and JP. These pharmaceutical vials with excellent barrier properties can be washed, autoclaved, sterilized, depyrogenated, filled, closed and inspected just like standard containers.
SCHOTT TopLyo® for optimum efficiency of the lyophilisation process
SCHOTT TopLyo®
SCHOTT TopLyo® vials improve the freeze drying process and consequently the results. The ultra-thin hydrophobic layer (40-100 nm and transparent) along with the optimized geometry of the vials prevent the collapse of the lyophilization cake and almost completely reduce the residual volume. The geometric design is dimensioned for an enhanced thermal transfer and a dramatic reduction of glass breakage.
The "lotus effect" of SCHOTT TopYieldTM vials is achieved through special coating.
SCHOTT TopYieldTM - Minimize the residual volume of liquid drugs
The special hydrophobic surface on the inside of a SCHOTT TopYieldTM vial is waterrepellent so that practically nothing can cling to its walls.
With conventional pharmaceutical vials, about 10-20% of the medication usually remains inside the container due to the fact that it cannot be emptied completely because of its rougher surface. SCHOTT TopYieldTM, however, allows for almost all of the medication to be administered. This effect especially leads to cost savings in the case of expensive medications because, in the past, pharmaceutical companies have been forced to overfill these containers accordingly in order to ensure that the required dosage recommended by the doctor actually leaves the vial.
SCHOTT TopYieldTM remains completely stable with respect to its hydrophobic layer during all types of pharmaceutical procedures and therefore reduces the risk of delamination with various drug formulations.
PICVD coating technology - proven a million times over
SCHOTT PI-Coating® - assurance through single station coating
The coating technology PICVD (Plasma Impulse Chemical Vapor Deposition) was developed by SCHOTT. It is a validated process that is proven a million times over. A three-stage inspection (100% on-site inspection of each reactor, an inspection of the process parameters and monitoring the system) enables 100% pharmaceutical quality.
