SCHOTT TopLine Options for Superior Shelf Life

SCHOTT Type I plus® – Reduced Drug Container Interaction

Protein adsorption and leaching from primary packaging are known to be root causes of reduced shelf life in sensitive formulations. Metal ion leaching from type I glass leads to a pH shift in water for injectable or unbuffered solutions and can decrease stability or activity of biopharmaceuticals.

SCHOTT Type I plus® vials have an inside SiO2 coating with outstanding barrier properties. This reduces the interaction between drug product and container surface to a bare minimum, thereby providing a superior packaging solution for sensitive ingredients.


  • Chemically uniform: pure silica (SiO2 coating)
  • Layer thickness: 100 – 200 nm
  • Non-porous, covalent bond between glass matrix and coating layer
  • Fill + finish processability equivalent to uncoated type I glass containers
  • Verified barrier owing to a predefined quantitative limit value of 0.17 μg/ml Na for all vial sizes


  • Increased shelf life stability for sensitive drug formulations
  • Minimized adsorption of proteins in liquid formulations – also prior to lyophilization
  • Minimized adsorption of radioactive molecules


2R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R and 100R ISO formats. Customization available on request.
SCHOTT uses Cookies on this Website to enhance the user experience and provide the best possible Service. By continuing to browse the Website, you consent to our use of Cookies.